Phosphomimetics are amino acid substitutions that mimic a phosphorylated protein, thereby activating the protein. Within cells, proteins are commonly modified at serine, tyrosine and threonine amino acids by adding a phosphate group. Phosphorylation is a common mode of activating or deactivating a protein as a form of regulation. However some non-phosphorylated amino acids appear chemically similar to phosphorylated amino acids. Therefore, by replacing an amino acid, the protein may maintain a higher level of activity. For example, aspartic acid can be considered chemically similar to phospho-serine, due to it also carrying a negative charge. Therefore, when an aspartic acid replaces a serine, it is a phosphomimetic of phospho-serine and can imitate the protein always in its phosphorylated form. However, differences between the phosphomimetic compound and the phosphorylated residue, notably differences in Ramachandran distributions, charge states and size, can alter the protein sufficiently to result in significant differences in behavior. Phosphonate-based compounds have been used as phosphotyrosine analogues, as they are less enzyme labile and are physiologically more stable.
"}{"type":"standard","title":"Puerto Rico Highway 693","displaytitle":"Puerto Rico Highway 693","namespace":{"id":0,"text":""},"wikibase_item":"Q64085196","titles":{"canonical":"Puerto_Rico_Highway_693","normalized":"Puerto Rico Highway 693","display":"Puerto Rico Highway 693"},"pageid":60529731,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c0/PR_secondary_693.svg/330px-PR_secondary_693.svg.png","width":320,"height":256},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c0/PR_secondary_693.svg/750px-PR_secondary_693.svg.png","width":750,"height":600},"lang":"en","dir":"ltr","revision":"1268998165","tid":"e0917bdd-d0f4-11ef-8831-b59ef84e1e6b","timestamp":"2025-01-12T14:52:43Z","description":"Highway in Puerto Rico","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Puerto_Rico_Highway_693","revisions":"https://en.wikipedia.org/wiki/Puerto_Rico_Highway_693?action=history","edit":"https://en.wikipedia.org/wiki/Puerto_Rico_Highway_693?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Puerto_Rico_Highway_693"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Puerto_Rico_Highway_693","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Puerto_Rico_Highway_693","edit":"https://en.m.wikipedia.org/wiki/Puerto_Rico_Highway_693?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Puerto_Rico_Highway_693"}},"extract":"Puerto Rico Highway 693 (PR-693) is a road located between the municipalities of Dorado, Puerto Rico and Vega Alta, passing through downtown Dorado. It begins at its intersection with PR-2 and PR-165 in Río Lajas and ends at PR-690 in Sabana. It is a short divided highway in southern Dorado, which serves as an alternate route for PR-165 west of Río de la Plata.","extract_html":"
Puerto Rico Highway 693 (PR-693) is a road located between the municipalities of Dorado, Puerto Rico and Vega Alta, passing through downtown Dorado. It begins at its intersection with PR-2 and PR-165 in Río Lajas and ends at PR-690 in Sabana. It is a short divided highway in southern Dorado, which serves as an alternate route for PR-165 west of Río de la Plata.
"}{"type":"standard","title":"Javanese sacred places","displaytitle":"Javanese sacred places","namespace":{"id":0,"text":""},"wikibase_item":"Q6165231","titles":{"canonical":"Javanese_sacred_places","normalized":"Javanese sacred places","display":"Javanese sacred places"},"pageid":2590190,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d3/COLLECTIE_TROPENMUSEUM_Beeld_van_Dewi_Sri_de_rijstgodin_TMnr_60016918.jpg/330px-COLLECTIE_TROPENMUSEUM_Beeld_van_Dewi_Sri_de_rijstgodin_TMnr_60016918.jpg","width":320,"height":437},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/d/d3/COLLECTIE_TROPENMUSEUM_Beeld_van_Dewi_Sri_de_rijstgodin_TMnr_60016918.jpg","width":513,"height":700},"lang":"en","dir":"ltr","revision":"1217526567","tid":"e38c6796-f3fc-11ee-b75a-cd6b11655983","timestamp":"2024-04-06T10:03:17Z","description":"Locations in Java, Indonesia","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Javanese_sacred_places","revisions":"https://en.wikipedia.org/wiki/Javanese_sacred_places?action=history","edit":"https://en.wikipedia.org/wiki/Javanese_sacred_places?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Javanese_sacred_places"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Javanese_sacred_places","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Javanese_sacred_places","edit":"https://en.m.wikipedia.org/wiki/Javanese_sacred_places?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Javanese_sacred_places"}},"extract":"Javanese sacred places are locations on the Island of Java, Indonesia that have significance from either village level through to national level as sacred, and in most cases deserve visitation—usually within the context of ziarah regardless of the ethnicity or religion of the visitor. The dominant form for many places is a sacred grave, or a place associated with persons considered to have special attributes in the past—like Wali Sanga or Royalty.","extract_html":"
Javanese sacred places are locations on the Island of Java, Indonesia that have significance from either village level through to national level as sacred, and in most cases deserve visitation—usually within the context of ziarah regardless of the ethnicity or religion of the visitor. The dominant form for many places is a sacred grave, or a place associated with persons considered to have special attributes in the past—like Wali Sanga or Royalty.
"}